By Louis Denis (auth.), Professor Dr. Louis Denis (eds.)
The advent of maximal androgen blockade as a medical treatment by means of Brachi and Labrie greater than a decade in the past resulted in a tremendous controversy at the scientific use of antiandrogens within the remedy of prostate melanoma. 3 consensus conferences have been as a consequence geared up with the aid of the yankee melanoma Society, the Urological staff of the eu association for examine and therapy of melanoma and the overseas Prostate healthiness Council. the 1st result of the meta-analysis of twenty-two trials didn't placed an finish to the debate, although, and clinicians have been left pressured via conflicting reviews released via dozens of specialists. The assembly in the back of the current quantity created a discussion board for the scientists who constructed the medicine and expert clinicians to supply a consensus. the result's an outline of the sector, condensed from 1000s of guides. the knowledge has been up to date to supply unique scientific symptoms for using antiandrogens together remedies and monotherapy for the person sufferer. we are hoping that this workforce attempt will facilitate ongoing discussions and result in stronger sufferer care in addition to elevated wisdom of the medicine which are so very important to our sufferers' caliber of lifestyles and survival.
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Extra info for Antiandrogens in Prostate Cancer: A Key to Tailored Endocrine Treatment
And what has been achieved? There are still no antiandrogenic preparations available for local use (topical application), although there is a certain need for them. Because of the effects of antiandrogens on, for example, spermatogene- sis, libido and potency, the systemic treatment of men with acne problems or baldness is not possible. The ideal solution would be a topically active antiandrogen without systemic sideeffects, but this problem has not yet been solved. Dorfman also mentioned hypertrichoSiS but, since androgens are not involved in the aetiology of this disorder, a therapeutic effect of antiandrogens is also unlikely.
Mol Pharmacol 1969 (5):428-431 Becker H, Dusterberg Band Klosterhalfen H: Bioavailability of cyproterone acetate after oral and intramuscular application in men. Urollnt 1980 (35): 381 Gerhards E, Gutsche H and Riemann J: Biodynamik von Cyproteronacetat nach oraler Verabreichung beim Menschen. Arzneimittelforschung 1973 (13): 1550 Bhargawa AS, Seeger A and Gunzel P: Isolation and identification of 15-B-hydroxy cyproterone acetate in dog, monkey and man. Steroids 1977 (30):407 Speck U, Jentsch D, Kuhne G, Schulze PE and Wendt H: Bioverfugbarkeit und Pharmakokinetik von Cyproteronacetat-14C nach Applikation als 50-mgTablette.
There were two possibilities: either CPA inhibited the androgen biosynthesis in the fetal testes or this compound inhibited the action of androgens in one way or another directly at the target organ level. The following experiment proved the second theory to be correct (see Fig. 3). In this experiment, castrated mice were given testosterone propionate. The parameters used for androgenicity were seminal vesicle and prostate weights. As can be seen, the prostate and seminal vesicle weights in castrated animals can be maintained by testosterone propionate.