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By Christopher M. Loftus

​This publication is an up to date reference on all facets of anticoagulation and hemostasis in neurosurgery. After a gap part on simple rules and drug periods in present use, distinct attention is given to coagulation matters proper to all sufferers, not only neurosurgical ones. The assurance contains, for instance, deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. numerous very important matters particular to neurosurgical perform are then addressed, and a precis of present instructions and top practices is equipped. by means of bringing jointly the newest wisdom from around the self-discipline, this e-book will function a legitimate foundation for trained determination making in surgical perform. it is going to be of day-by-day price for neurosurgeons and trainees around the world and also will be of curiosity to emergency room physicians, surgeons typically, severe care physicians, neurologists, and sanatorium drugs specialists.

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The thrombin–thrombomodulin complex activates plasma protein C, and activated protein C (APC) binds free plasma protein S. The stabilized APC–protein S complex hydrolyzes factors Va and VIIIa to slow thrombin generation and fibrin formation. Protein S circulates either free or covalently bound to the complement binding protein C4bBP. Bound protein S cannot participate in the protein C anticoagulant pathway; only free plasma protein S is available to serve as the APC cofactor. 2 Laboratory Assessment of Physiologic and Pathologic Hemostasis Functional assays detect both quantitative and qualitative protein C deficiencies.

The most notable complication is spontaneous ICH that occurs secondary to hypoprothrombinemia. Other side-effects include ecchymosis, purpura, and hematuria. Patients can also experience skin necrosis secondary to the depletion of protein C and S mentioned earlier; this leads to thrombosis of vessels supplying the skin in the extremities. 36 % [11]. 7 % of these events [10]. When patients present with ICH while on VKAs, the mortality rate is estimated to reach 46–55 % [13, 14] with significant long-term disability in those that do survive [15, 16].

The presence of large platelets on the blood film associated with elevated 20 mean platelet volume often indicates rapid platelet turnover, such as in immune thrombocytopenic purpura. Bleeding Time Test for Platelet Function The bleeding time test is the original test of platelet function. Using a blood pressure cuff inflated to 40 mmHg, a controlled puncture wound is made with a calibrated spring-loaded lancet triggered on the volar surface of the forearm, and the resulting wound is blotted every 30 s until bleeding stops.

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