Hematology

Download Aplastic Anemia: Pathophysiology and Treatment by Hubert Schrezenmeier, Andrea Bacigalupo PDF

By Hubert Schrezenmeier, Andrea Bacigalupo

This ebook takes account of the latest findings in laboratory examine and scientific trials to supply a accomplished and up to date reference at the pathophysiology, epidemiology, analysis and therapy of received and inherited aplastic anemia. in addition to supplying an in depth assessment of the pathophysiology of the disorder, the overseas group of authors covers all facets of administration, together with the demonstrated methods of bone marrow transplantation and immunosuppressive remedy, new ways equivalent to using hematopoietic progress components and escalated immunosuppression, and arguable concerns comparable to stem mobilephone transplantation. additionally integrated is a vital overseas consensus record on therapy, and a last part concentrates at the inherited syndrome Fanconi's anemia. designated remedy guidance are given, making this the definitive source for hematologists and different clinicians fascinated with the administration and supportive care of sufferers with aplastic anemia. Scientists drawn to bone marrow failure also will locate this a useful reference.

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Extra info for Aplastic Anemia: Pathophysiology and Treatment

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Cosman, D. and Lyman, S. D. (1990) Identification of a ligand for the c-kit proto-oncogene. Cell, 63, 167–74. , Zsebo, K. , Speck, B. and Nissen, C. (1992) Stem cell factor stimulates the in vitro growth of bone marrow cells from aplastic anemia patients. Blood, 79, 3196–202. , Speck, B. and Nissen, C. (1993) Levels of soluble stem cell factor in serum of patients with aplastic anemia. Blood, 81, 3259–64. , Lyman, S. , Speck, B. and Nissen, C. (1996) Flt-3 ligand level reflects hematopoietic progenitor cell function in aplastic anemia and chemotherapy-induced bone marrow aplasia.

Metcalf, D. (1986) The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors. Blood, 67, 257–67. , Kamachi, S. and Fukushima, M. (1989) Quantiative enzyme immunoassay for human granulocyte colony-stimulating factor (G-CSF). Journal of Immunological Methods, 118, 187–92. Muench, M. , Roncarolo, M. , Hannum, C. , Lee, F. and Namikawa, R. (1995) Flk-2/flt-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver. Blood, 85, 963–72.

The use of these cytokines in combination with immunosuppressive agents could reduce early infections and, therefore, increase the number of patients surviving long enough to achieve a hematological response. , 1995). Ongoing randomized prospective studies combined with immunosuppression and cytokines will reveal the usefulness of cytokines in the treatment of AA. , Kodera, Y. and Matsuyama, T. (1991) Correlation of response of aplastic anemia to antilymphocyte globulin with in vitro lymphocyte stimulatory effect: predictive value of in vitro test for clinical response.

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