Hematology

Download Biologic Therapy of Leukemia (Contemporary Hematology) by Matt Kalaycio PDF

By Matt Kalaycio

Fascinating new "biologic" remedies for treating leukemia are showing so speedily that clinicians usually locate it tough to make educated judgements approximately their use while making sufferer remedy judgements. Biologic treatment of Leukemia summarizes and studies the entire on hand information bearing on those state of the art biologic treatments in order that training clinicians could make the right kind patient-care offerings. the following the busy medical professional will locate in a single handy position the most important details at the makes use of and barriers of the foremost biologic treatments for leukemia, different biologic options for its therapy, the administration of sufferers being taken care of with such biologic brokers, and the present and destiny position of rising biologic brokers.

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Importantly, a dose-response effect was noted when the patients at various dose levels were analyzed (Fig. 1). The response rate of 80% at the highest dose levels, 75% if only patients with B-CLL are considered, is far higher than was previously noted at standard doses of rituximab. Dose escalation, then, appears to overcome either the antibody resistance of the leukemic Chapter 3 / Unconjugated Monoclonal Antibodies 33 Fig. 1. Dose-response effect of rituximab for patients with chronic lymphocytic leukemia.

The use of DLI was pioneered in patients who relapsed after alloBMT. The theory was straightforward: if a patient relapsed after receiving an ablative alloBMT, and if that patient also did not have overt clinical GVHD, then the infusion of additional donor cells (DLI) might be sufficient to produce a cellular immunotherapeutic effect and result in clinical remission. Initially, small studies investigated the use of donor buffy coat leukocytes for patients with CML who relapsed after alloBMT and found that a combination of α interferon and DLI resulted in both clinical and cytogenetic remissions (47,48).

13. Uzunel M, Mattsson J, Jaksch M, Remberger M, Ringdén O. The significance of graft-versus-host disease and pretransplantation minimal residual disease status to outcome after allogeneic stem cell transplantation in patients with acute lymphoblastic leukemia. Blood 2001;98:1982–1985. 14. Mendoza E, Territo M, Schiller G, Lill M, Kinkel L, Wolin M. Allogeneic bone marrow transplantation for Hodgkin’s and non-Hodgkin’s lymphoma. Bone Marrow Trans 1995;15:199–303. 15. Ratanatharathorn V, Uberti J, Karanes C, et al.

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