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Download Cerebral Cortex: Neurodegenerative and Age-Related Changes by Marilyn S. Albert, Mark B. Moss (auth.), Alan Peters, John PDF

By Marilyn S. Albert, Mark B. Moss (auth.), Alan Peters, John H. Morrison (eds.)

This quantity of Cerebral Cortex is devoted to Sir John Eccles, who used to be an lively member of the advisory board for the sequence until eventually his demise in could 1997. His enter as to what issues might be lined in destiny volumes of this sequence may be sorely overlooked. the current quantity is worried with neurodegenerative issues and age­ similar adjustments within the constitution and serve as of the cerebral cortex, a subject that has attracted expanding curiosity as durability and the variety of elderly participants within the inhabitants bring up. even supposing a lot of the study at the neurodegenerative results of getting older has been headquartered on Alzheimer's affliction, many of the getting older popu­ lation are not via this affliction. they're going to, besides the fact that, be laid low with the results of ordinary getting older, so the 1st few chapters of this quantity are con­ cerned with that subject. bankruptcy 1, by way of Marilyn S. Albert and Mark B. Moss, supplies an account of the cognitive alterations that accompany basic human getting older. bankruptcy 2, by means of Mark B.

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Additional info for Cerebral Cortex: Neurodegenerative and Age-Related Changes in Structure and Function of Cerebral Cortex

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1988), we found no significant difference in trials or errors to learning criterion between a group of six young adult and a group of six advanced-aged monkeys on three different simple discrimination tasks (brightness, hue, and pattern). , 1997), suggesting that simple discrimination learning is preserved until the end of the life span. 2. , 1981; Cowey and Gross, 1970) and in humans (Oscar-Berman and Zola-Morgan, 1980). Concurrent-discrimination tasks assess the ability to learn associations between reward and given stimulus objects in the presence of proactive and retroactive interference.

It has been hypothesized that these declines are related to alterations in neurotransmitter levels in subcortical nuclei (discussed further below). In monkeys, initial evidence suggests that procedural learning, at least with respect to motor skill learning, is only minimally affected by age. The performance of aged monkeys on a timed task, in which a piece of hard candy is moved along a metal form with a varying number and angle of curves, did not differ significantly either in latency or trials-to-criterion, as compared with young adult monkeys (Ronald, 1992).

1993, Morphological analyses of the brains of behaviorally characterized aged nonhuman primates, Neurobiol. Aging 14:671-672. , 1983, The effect of advanced old age on the neurone content of the cerebral cortex: Observations with an automatic image analyser point counting method, J Neurol. Sci. 58:233-244. , 1990, Analysis of alpha-2 adrenergic agonist effects on the delayed non-matching-to-samp1e performance of aged rhesus monkeys, Neurobiol. Aging 11:583-590. , 1994, Dopamine D2 receptor mechanisms in the cognitive performance of young adult and aged monkeys, Psychopharmacology (Berlin) 116:143-151.

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