Hematology

Download Chemokine Receptors and AIDS (Infectious Disease and by Obrien PDF

By Obrien

This authoritative reference offers the newest learn at the position of chemokines, chemokine receptors, and genetic variability within the susceptibility, prevention, and therapy of HIV-1-exploring new healing thoughts for greater remedy of HIV-1 contaminated sufferers via blockading chemokine receptor expression. With contributions from professional specialists within the box, Chemokine Receptors and AIDS info ·the position of chemokine receptors in HIV-1 an infection and pathogenesis ·the id and function of the CCR5-D32 allele in HIV an infection ·potential novel how to deal with HIV-1 an infection by means of blocking off or down-regulating the CCR5 and CXCR4 HIV-1 coreceptors ·strategies utilizing monoclonal antibodies, small molecules, and ribosymes ·and extra! supplying greater than 1200 present references, Chemokine Receptors and AIDS is a vital reference for infectious illness experts, epidemiologists, virologists, immunologists, pharmacologists, medicinal chemists and biochemists, microbiologists, and clinical scholars in those disciplines.

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Extra resources for Chemokine Receptors and AIDS (Infectious Disease and Therapy)

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L. R. Shah, R. O. D. M. M. Strieter. 1995. Macrophage inflammatory protein-I-beta - a c-c chemokine in osteoarthritis. Clinical Immunology and Immunopathology 77:307. 93. , lB. L. W. Hancock. 1999. CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-Ialpha and IP-lO are expressed in demyelinating brain lesions. Sci. A. 96:6873. 94. A Boisvert, and LX Curtiss. 1998. Chemokines and atherosclerosis. Lipidol. 9:397. 95. , S. Su, W. 1. Oppenheim. 1998. Chemokines, receptors, and their role in cardiovascular pathology.

The phosphorylation deficient mutants of CXCRI (M2-CXCRI), CXCR2 (33IT-CCR2) and CCRI (S3Figure 3 Sites for chemokine receptors cross-desensitization and regulation of signal strength. Chemokines activate signaling pathways through the Gni and GJ3y G protein subunits to activate phospholipase C (pLCJ3) and increase second messengers. Second messenger activated kinases (PKC, PKA) phosphorylate susceptible receptors and PLCJ3 to specifically inhibit Gn and GJ3y mediated PLCJ3 activation. Potential sites for regulation of signal strength, such as regulators of G-protein signaling (RGS) and modification of GJ3Y, are also indicated.

Dis. 4:54. 119. , M. Tani, 1. Jensen, V. Pierce, C. Lucchinetti, VA Folcik, S. Qin, 1. Rottman, F. M. L. Frederiksen, and RM. Ransohoff. 1999. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. 1nvest. 103:807. 120. , V, 1. H. P. Tensen, and CJ. De Groot. 1999. Expression of MCP-l by reactive astrocytes in demyelinating multiple sclerosis lesions. AmJPathol. 154:45. 121. L. K. Arya, RC. Gallo, and P. Lusso. 1995. Identification of rantes, mip-I-alpha, and mip-l-beta as the major hiv-suppressive factors produced by cd8(+) t-cells.

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