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By Prof. Dr. Hans Schmidt (auth.)

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Amer. J. Vet. Res. 11, 98 (1950). 46. WEDGWOOD, R. , The influence of antibodies on the activity of the properdinsystem. Vortrag Nr. 296. VI. Kongr. Europ. Ges. Hamatologie Abstract. S. 209. (Kopenhagen 1957). 47. , C. F. HINZ jr. and L. WURZ, Preparation and properties of antihuman properdin rabbitserum. Science 125, 1244 (1957). 48. POND MAN, K. , J. HOOGENDIJK, M. VAN DER HART and I. J. VAN LOGHEM. The preparation of an antibody against properdin. Vortrag 297. VI. Kongr. Europ. Ges. Hamatologie (Kopenhagen 1957).

94, 230 (1957). 18a • HINz, C. F. jr. und L. PILLEMER, Requirement for properdin in hemolysis of human erythrocytes treated with tannic accid. J. Clin. Invest. 34, 912 (1955). 19. BARLOW, J. , H. V. VUNAKIS and L. LEVINE, Bacteriophage neutralization as assay of properdin levels in fresh serum. Fed. Proc. 16, 405 (1957). 20. BARLow, J. , L. LEVINE and H. v. VUNAKIS, Studies on the inactivation of phage by the properdin-systems. Vox sanguinis 3, 66 (1958). 21. PERNIS, B. und M. TURRI, Osservazioni suI dosaggio della properdina mediante la neutralizzione del bacteriofago.

Die Messung mittels Lyse von mit Tannin behandelten Erythrozyten Man nimmt an, daB die auf S. 102 beschriebene Eigenschaft von Properdin, die Blutzellen von Kranken mit paroxysmaler Hamoglobinurie (Typ Marchiafava - Micheli) zu lOsen, darauf beruht, daB der dieser Krankheit zugrunde liegende morbide ProzeB die fiir die Properdinbindung bereits natiirlich an Blutzellen vorhandenen Rezeptoren demaskiert, so daB die Erythrozyten fiir die P-Wirkung disponibel werden. Wie HINZ, ABRAHAM und PILLE MER (18) fanden, konnen normale Blutzellen auch durch geeignete Tanninbehandlung fiir die P-Wirkung empfanglich gemacht werden, so daB die Lyse so vorbehandelter Blutzellen durch ein Serum als MaB fiir des sen Gehalt an Properdin benutzt werden konnte.

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