By Gerard Hornstra M.D. (auth.)
Knowledge of mechanisms occupied with the pathogenesis of occlusive arterial dis eases is key for the layout of prevention and remedy. a sequence of stories in accordance with in vitro investigations, the experimental animal and the man or woman have slowly elevated our knowing of cardiovascular ailments and unveiled their secrets and techniques to us. over the past 60 years it's been commonly assumed that nutritional fat and lipids and the prevalence of atherosclerosis are heavily comparable. but, no matter if epidemiological reports essentially point out the lifestyles of an organization among the quantity of composition of nutritional lipids and morbidity and mortality of aerobic vascular disorder, our simple wisdom on reason and influence continues to be hidden in a cloud of uncertainty. the current booklet discusses the relation among nutritional lipids and arterial throm bosis, which latter approach has been saw within the coronary arteries in as much as ninety% of topics with acute myocardial infaction. during this quantity Dr. Hornstra, who has occupied himself with thrombosis examine with never-failing enthusiasm, nice ability and important process for the final fifteen years, attempts to set up attainable hyperlinks among lipid metabolism and thrombosis. His literature stories are accomplished and his investigations are amazing in that they provide a brand new measurement and a brand new technique to analyze of lipids and thrombosis.
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Extra info for Dietary Fats, Prostanoids and Arterial Thrombosis
Example text
FATTY ACID DERIVATIVES Fatty acids, especially the long-chain types, have strong deterging properties and are very toxic for the organism. Therefore, under normal circumstances, tissue free fatty acid levels are very low. g. for prostaglandins). 1. Triglycerides Triglycerides (triacyglycerols) are esters of glycerol and fatty acids. One molecule of glycerol can bind three fatty acid molecules (Fig. 6). These fatty acids may be similar or (partly) different. In the body, triglycerides constitute the major fatty acids depot located in the adipose tissue.
7). At the 2-position this group is largely a (poly-)unsaturated fatty acid; at the I-position, it usually is a saturated fatty acid. Sometimes, the hydrocarbon chain is attached to the I-position of the glycerol moiety via an ether H2 oII C-O--C--R1 H o II C--O--C--R2 o II O--C-- R3 Fig. 6. Structure of triglyceride molecule. R I , R2 and R3: fatty acid residues 22 Fig. 7. Structure of phospholipid molecule. RI and Rz: fatty acid residues; R3: alcohol group. AI, Az, C and D: site of action of respective phospholipases linkage, forming an alkyl ether phospho glyceride.
The TxA2 produced by and the ADP released from the collagen-activated platelets also causes other platelets to aggregate. When the platelet-TxA 2 production is inhibited by pre-treatment of the platelets with aspirin, platelet release and aggregation diminish proportionally. However, this inhibition can simply be overcome by increasing the trigger-strength [881] without reactivation of platelet TxAz-formation [273]. Moreover, in vitro inhibition of thromboxane synthase does not necessarily result in the prevention of platelet aggregation [52].
