By Balwinder, M.D. Singh
Disseminated intravascular coagulation is a devastating syndrome characterized via the systemic activation of common activation of the coagulation cascade and thrombosis, which can bring about serious bleeding and should result in organ failure. fresh reviews have proven that the prevalence of DIC is reducing, in particular in males. regardless of the advancements in health and wellbeing care supply, the morbidity and mortality as a result of DIC continues to be very excessive. This publication offers a huge well timed replace at the medical manifestations, very important possibility components, and remedy recommendations for DIC, and gives in-depth details on pathophysiological facets and numerous diagnostic rankings used to diagnose DIC.
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Extra resources for Disseminated Intravascular Coagulation (DIC): Clinical Manifestations, Diagnosis and Treatment Options
Individuals who are heterozygotes for these deficiencies have been traditionally considered to be at high risk of developing DIC without an underlying disorder. Cases linking these defects with DIC and neonatal purpura fulminans have are well documented in the literature [76-78]. Protein C is a glycoprotein which circulates in plasma in an inactive form. It‘s a vitamin K dependent factor which also requires the presence of protein S and anionic phospholipids for its activity . Protein C gets converted into its active form [APC] by the action of thrombin-thrombomodulin complex.
Thrombomodulin (TM) is a membrane-bound glycoprotein initially identified on vascular endothelium , and later on leucocytes, smooth muscle cell, platelet, and cardiomyocyte [10, 11]. TM is also expressed in some cancer cells and influences cancer growth and metastasis [12, 13]. TM protein has 557 amino acids, and its structure consists of 5 domains including a highly charged N-terminal lectin-like domain (D1), a domain with six epidermal growth factor (EGF)-like structures (D2), a serine and threonine-rich domain (D3), a transmembrane domain (D4) and a cytoplasmic domain (D5) .
37] Gouin-Thibault I, Achkar A, Samama MM. The thrombophilic state in cancer patients. Acta Haematol. 2001;106:33-42.  A. Ravikumar, Vivek Sasindran, K. Senthil, John Samuel, Thirumaran. Disseminated Intravascular Coagulation syndrome — ENT surgeon‘s perspective. ndian J Otolaryngol Head Neck Surg. 2006 October; 58: 384–386.  Gordon SG, Mielicki WP. Cancer procoagulant: a factor X activator, tumor marker and growth factor from malignant tissue. Blood Coagul Fibrinolysis 1997; 8:73.  Gordon SG, Franks JJ, Lewis B.