By Peter B. Dervan, Adam T. Poulin-Kerstien (auth.), Michael J. Waring, Jonathan B. Chaires (eds.)
The editors have assembled an eclectic number of articles that supply an excellent evaluation of the present cutting-edge in small molecule-nucleic acid targeting.......
As indicated by way of its common name, this most modern contribution to the Topics in present Chemistry sequence isn't really intended to be entire. fairly, quite a few themes on the vanguard of small molecule-nucleic acid biochemistry are mentioned in nice aspect. This quantity may be of substantial use either to researchers within the box and to those that desire to flow into this intriguing area.
Paul J. Hergenrother, collage of Illinois at Urbana-Champaign, JA059748D, J.AM.CHEM.SOC., Vol. 128, no. 10, 2006
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2 New Metrics: the Specificity Sum (SS) and SS/Cmax . . . . . . . . 42 42 45 4 Quantitative Analysis of Competition Dialysis Data: Validation . . . . . 49 5 Summary and Outlook . . . . . . . . . . . . . . . . 50 . . . . . . . . . . . . . . . . . . . . 51 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Abstract Competition dialysis is a powerful new tool for the discovery of ligands that bind to nucleic acids with structural- or sequence-selectivity.
Abstract Competition dialysis is a powerful new tool for the discovery of ligands that bind to nucleic acids with structural- or sequence-selectivity. The method is based on firm thermodynamic principles and is simple to implement. In the competition dialysis experiment, an array of nucleic acid structures and sequences is dialyzed against a common test ligand solution. After equilibration, the amount of ligand bound to each structure or sequence is determined spectrophotometrically.
One should note in Fig. 2 the differences in the amounts bound among the three compounds. Each panel is scaled the same. The amounts bound are directly proportional to the relative binding affinities of each compound for the various nucleic acid structures. Thus, while DODC is highly selective, its binding affinity is comparatively low. Adriamycin, in contrast, has comparatively high affinity for the various duplex forms to which it binds. Using the first generation competition dialysis assay that used 13 nucleic acid structures and sequences, 126 different compounds were studied.
