
By Peter B. Dervan, Adam T. Poulin-Kerstien (auth.), Michael J. Waring, Jonathan B. Chaires (eds.)
The editors have assembled an eclectic number of articles that supply an excellent evaluation of the present cutting-edge in small molecule-nucleic acid targeting.......
As indicated by way of its common name, this most modern contribution to the Topics in present Chemistry sequence isn't really intended to be entire. fairly, quite a few themes on the vanguard of small molecule-nucleic acid biochemistry are mentioned in nice aspect. This quantity may be of substantial use either to researchers within the box and to those that desire to flow into this intriguing area.
Paul J. Hergenrother, collage of Illinois at Urbana-Champaign, JA059748D, J.AM.CHEM.SOC., Vol. 128, no. 10, 2006
Read Online or Download DNA Binders and Related Subjects: -/- PDF
Best nonfiction_4 books
Learn & Play Sudoku for Fifth Grade
It is time for Sudoku! celebrate educating and studying the elemental ideas and methods of Sudoku whereas training puzzle-solving abilities. This enjoyable studying publication contains step by step instructions, bring to a halt items, puzzle blockers, and 3 adaptations of puzzles. .. forty five puzzles in all! 72pp.
Variation Tolerant On-Chip Interconnects
This booklet provides layout strategies, research and implementation of excessive functionality and gear effective, edition tolerant on-chip interconnects. Given the layout paradigm shift to multi-core, interconnect-centric designs and the rise in assets of variability and their influence in sub-100nm applied sciences, this booklet should be a useful reference for a person all for the layout of subsequent new release, high-performance electronics structures.
- From a Sacred Source: Genizah Studies in Honour of Professor Stefan C. Reif (Etudes Sur Le Judaisme Medieval)
- Deep Water (Cliff Hardy series)
- Monitoring and evaluating social programs in developing countries: a handbook for policymakers, managers, and researchers, Page 94
- Memory bank for chemotherapy
- Men in Blue: Badge of Honor 01
Additional resources for DNA Binders and Related Subjects: -/-
Sample text
2 New Metrics: the Specificity Sum (SS) and SS/Cmax . . . . . . . . 42 42 45 4 Quantitative Analysis of Competition Dialysis Data: Validation . . . . . 49 5 Summary and Outlook . . . . . . . . . . . . . . . . 50 . . . . . . . . . . . . . . . . . . . . 51 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Abstract Competition dialysis is a powerful new tool for the discovery of ligands that bind to nucleic acids with structural- or sequence-selectivity.
Abstract Competition dialysis is a powerful new tool for the discovery of ligands that bind to nucleic acids with structural- or sequence-selectivity. The method is based on firm thermodynamic principles and is simple to implement. In the competition dialysis experiment, an array of nucleic acid structures and sequences is dialyzed against a common test ligand solution. After equilibration, the amount of ligand bound to each structure or sequence is determined spectrophotometrically.
One should note in Fig. 2 the differences in the amounts bound among the three compounds. Each panel is scaled the same. The amounts bound are directly proportional to the relative binding affinities of each compound for the various nucleic acid structures. Thus, while DODC is highly selective, its binding affinity is comparatively low. Adriamycin, in contrast, has comparatively high affinity for the various duplex forms to which it binds. Using the first generation competition dialysis assay that used 13 nucleic acid structures and sequences, 126 different compounds were studied.