By H. P. Rang
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2 shows the result of such an experiment. Fig. 2b shows the normal preparation in 4 mM K control solution. ___. J 11 mV '----' 1 mV DA ACh 200 nA 60 nA FIG. 2. The effect of changing the external potassium concentration on the ACh- and dopamine-induced hyperpolarization. The cell membrane potential was initially at -41 mY, and brought to this value after each change of solution by passing a current through the electrode. Normal control solution contained 4 mM potassium (b). Decreasing the external potassium concentration to zero (a) increased the hyperpolarization whilst increasing the external potassium concentration to 8 mM (c) decreased the hyperpolarization.
