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2011). , 2008). Overall, the elucidation of the functional role of the ccRCC activated signaling pathways could be useful for the identification of novel cancer markers or for the development of molecular–targeted therapeutic agents. Taking into account the biological localization and functional roles of genes up regulated in ccRCC, we propose a series of genes that could represent candidate biomarkers for further investigations (Table 7). , 2010 Table 7. List of candidate biomarker genes up regulated in ccRCC.

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8, pp. 825–831. ; Gill, H. (2003). Gene Expression Patterns in Renal Cell Carcinoma Assessed by Complementary DNA Microarray. 162, pp. 925–932. Iliopoulos O. (2006). Molecular Biology of Renal Cell Cancer and the Identification of Therapeutic Targets. 24, pp. 5593–5600. ; Mole, D. (2005). HIF Overexpression Correlates with Biallelic Loss of Fumarate Hydratase in Renal Cancer: Novel Role of Fumarate in Regulation of HIF Stability. Cancer Cell, Vol. 8, pp. 143–153. ; Robertson, C. (1990). Collecting Duct Carcinoma of the Kidney.

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